By Dr. med. Oscar Vargas-Machuca. This article is also available in german language.
How and why Alen® / Eveliza® are important for people with arthritis
Collagen in connective tissue is the most important substance in our body, accounting for almost 30% of the total proteins in our body. It is widely distributed throughout the body and is a constituent part of tendons, ligaments, cartilage, skin and bones, and its main function is to support the other tissues and organs. Its presence is fundamental, and its molecular integrity is a necessary condition for maintaining resistance and organic durability, which is why it is found in the strings and bands of tendons.
It integrates the binding of bone tissue and in cartilage and tendon it acts as a lubricant together with proteoglucans. It is a component of joints and intervertebral discs, and is also found in heart valves, the cornea, and the lens of the eye. Tropocollagen, the basic molecule of collagen, has a perfect special symmetry. It is made up of three polypeptide chains in a spiral configuration and has a high concentration of glycine and proline. These and other components are highly polarized and separated by regions saturated with glycine, proline and hydroxyproline. These regions also contain hydroxylated glycine, ascorbic acid, ferrous iron, ketoglutarate, and oxygen. This complex structure tends to form highly resistant fibrils, stronger than a steel thread.
However, this requires perfectly matched atomic and molecular components of excellent quality; otherwise, these highly specialized molecules become disorganized and lose their supportive function. Chronic Arthritis and its variations in humans are the result of just such disorganization of the collagen molecule, and it is suspected that it occurs due to the presence of enzymatic, antibodies such as collegians and to the depolarization of hyaluronic acid which occurs because of superoxide radicals.
In our species arthritis is increasing all the time because of our increasingly unnatural lifestyle. From the medical point of view its diagnosis and treatment pose many problems, and to date, despite extraordinary medical progress, no satisfactory solution has been found.
Although countless research, resulting in many hypotheses and theories, has been carried out, our knowledge of this disease is still insignificant. One such theory tried to show a correlation between immune system dysfunction and articular degeneration. Another theory propounded that the presence of cytokines explained the articular damage by the catabolic action of these catalytic molecules against collagen. Since joints are in the main formed by the union of two bones, which in certain circumstances are subject to enormous pressure, it follows that, to maintain their structural functioning, they require a constant balancing of the deterioration and regeneration of their components. We do not know the mechanism by which this balance is regulated, but we think that the cytokines act as messengers which carry the information for the repairing of these structures, in quality as weil as quantity.
This is more notable in swollen joints, where in addition to such elements as Iymphocytes and liquid, a large number of cytokines are formed and that at the expense of these messengers the metabolic balance of tissues, such as sinews, bones and cartilages, is modified. Cytokines perform the important function of accelerating the growth of connective tissue; they stimulate the liberation of catabolizing enzymes and pre-inflammatory prostaglandins. Cytokines also activate the re-absorption of the bone and cartilage tissue. Accordingly, it is logical to suspect that the so-called „pannus“ is an aggressive tissue, which proliferates from the conjunction of the articular capsule and the cartilage, and is attributable to the local action of cytokine. The pannus of rheumatoid arthritis progresses from the outside to the inside, passing through cartilage and bone. If this progress is not stopped (and there is no known way of doing this) the inevitable consequence is invalidity. The action of cytokine is still unknown in the process of articular destruction and all the chains of transformation have not been determined. Cytokines found in arthritis patients are derived from interleukin type 1; proceeding in the main from macrophage monocytes, but the classification has only been possible within vitro cultures of human and animal cells. It is also true that interleukin type 1 produces pathological alterations. Interleukin has only been obtainable in larger quantities in recent years, making it possible to carry out more generalized research directed to find inhibitory substances such as antibodies neutralizing Cytokines, which could be used as pharmacological agents to fight this disease, but it seems that the therapeutic horizon is still very distant. It is probable that we are very far from the real discovery of the origins of arthritis and its healing method, as the only evidence we have is the immune System response of an aggressive auto-immune type which appears in this disease. These theories propounded by M. Clapp of Basel reveal that the focusing of the collagen problems still requires a solution to act on the neutralization of the aggressive elements of collagen.
During the latter years of experimentation with Alen®/Eveliza®, it was revealed that patients who took it for obesity, diabetes, or premature aging, and who were also suffering from arthritis, had remarkable recoveries with regard to the latter.
Many people who could not walk recovered their lost mobility and pain and rigidity generally decreased. These shattering results lead us to submit a logical and reasonable theory, that Alen® / Eveliza® which are an ensemble of concentrated and assimilable nutritive components, can improve arthritis.
The problem we consider is as folIows: all investigation of reductionist medicine has been preoccupied with giving a solution to the inhibition of the aggressive factors attacking collagen. We believe that the natural solution to the problem lies in the collagen itself. At the beginning of this chapter we stressed, though briefly, the complexity of the collagen molecule, and that its atomic structure must maintain an electromagnetic and resonant stability in its atoms, so that its resistance is complete, qualities that can only be maintained if the components of the molecule are found in appropriate quantity and quality. Furthermore, these components must be replaced when they degenerate, which means maintaining an appropriate pool of the molecular basis for reconstruction with sufficient supply of protein and mineral elements to accommodate the reparation speed of these complicated molecules. This condition is not fulfilled in arthritic patients, we suspect, as the majority of diets in this technological age, as mentioned previously, do not contain sufficient essential nutritive elements.
Organisms submitted to such chronic deficiencies of essential factors slowly accumulate deficiencies in the cellular resistance, in general, and particularly, of the connective tissue, which, becoming increasingly impoverished, is less and less resistant and will be subject to the multiple mini traumatisms normally suffered daily by our joints.
This modified collagen tissue is unrecognizable to exploring enzymes, producing an immediate aggressive immune response which will try to eliminate these foreign-Iooking tissues whose structure have been altered due to lack of the correct molecular organization.
This collagen tissue is seen as real foreign bodies to the antibodies. Immediately, an avalanche of events accompanying the auto-immune system response occurs, establishing a process of elimination of these foreign bodies, with the automatic goal being to replace them by normal tissue. If the immunological activity then tends to a renovation of the quality of the deficient collagen this will inevitably only lead to similar structurally deficient tissue replacement, as the patient diet is itself deficient in the essential nutritive elements. A vicious circle of malnutrition and deficiency is thus established, where the outcome will be the progressive deterioration of those joints which work the most and support the most weight.
For the above reasons we consider ARTHRITIS, OSTEOARTROSIS AND ALL THE
DEGENERATIVE PROCESSES OF COLLAGEN as deficiency diseases.
Alen®/Eveliza® are highly assimilable nutritive substances and act in the arthritic patient to replace his nutritional deficit of all the essential factors required, re-establishing their complementarity and at the same time helping to repair and reconstruct the deteriorated collagen molecules which will recover their original structure. As this is achieved, the offensive antibodies will lose their aggressive behavior and will stop attacking the new collagen, its molecular structure and design now being correct and normal. So, the symptoms of the arthritic patient will improve.
For instructions on how and when to take Alen®/Eveliza® to correct these
discomforts given by these diseases, please contact us.
